Decision-Making Tool - NTOG

Decision-Making Tool

This tool helps evaluate treatment options based on specific criteria that are essential for assessing the overall benefit and cost-effectiveness of treatments. Each criterion has a scoring guideline to facilitate decision-making.

Criteria

Criteria Explanation Metrics and Scoring
Overall Survival (OS) Benefit Measures the median or mean survival extension provided by a treatment. Report as months gained; categorize as Low (<3m), Moderate (3-6m), High (>6m).
Hazard Ratio (HR) Indicates the relative risk reduction in death with treatment compared to control. <0.7 (Favorable), 0.7–0.9 (Moderate), >0.9 (Unfavorable)
Number Needed to Treat (NNT) The number of patients who need to be treated to prevent one adverse outcome. Low (<10), Moderate (10-20), High (>20)
Number Needed to Harm (NNH) The number of patients who need to be treated for one to experience harm. Low (<10), Moderate (10-20), High (>20); higher NNH preferred.
Quality-Adjusted Life Years (QALY) Estimates quality and length of life, adjusting for health-related quality of life. Measured as years; categorized as Low (<0.5), Moderate (0.5-1.0), High (>1.0)
Cost Direct cost of treatment, including associated healthcare utilization costs. Low (<10,000 EUR), Moderate (10,000-50,000 EUR), High (>50,000 EUR)

Examples of Decision Matrix for Treatment Options

Treatment Option OS Benefit HR NNT NNH QALY Cost Overall Score
Option A 5 months (Moderate) 0.68 (Favorable) 15 (Moderate) 25 (High) 0.8 (Moderate) 12,000 EUR (Moderate) 14/18
Option B 8 months (High) 0.28 (High) 10 (Low) 15 (Moderate) 1.2 (High) 45,000 EUR (Moderate) 16/18
Option C 3 months (Low) 0.85 (Neutral) 20 (High) 10 (Low) 0.4 (Low) 8,000 EUR (Low) 9/18

Treatment Score Calculator













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